Soluble ST2 protein as a new biomarker in patientswith precapillary pulmonary hypertension
نویسندگان
چکیده
منابع مشابه
Soluble ST2: A Novel Prognostic Biomarker of Heart Failure.
Previous studies have demonstrated the role of ST2 in predicting hospitalization and mortality in heart failure, independent of natriuretic peptides and other clinical variables. 9-17 In 2011, the U.S. Food and Drug Administration (FDA) delared the Presage ST2 Assay (Critical Diagnostics, San Diego, California, USA), which is typically used in conjunction with clinical evaluation as an aid in a...
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Provirus integration site for Moloney murine leukemia virus (Pim-1) is an oncoprotein overexpressed in lungs from pulmonary arterial hypertension (PAH) patients and involved in cell proliferation via the activation of the NFAT/STAT3 signaling pathway. We hypothesized that Pim-1 plasma levels would predict the presence of PAH and correlate with disease severity. Pim-1 plasma levels were measured...
متن کاملIdentification of serum soluble ST2 receptor as a novel heart failure biomarker.
BACKGROUND Using genomic technology, we previously identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes. The soluble receptor form of ST2 is secreted and detectable in human serum. This study tested the hypothesis that soluble ST2 levels in the serum of patients with severe chronic heart failure are increased in patients wi...
متن کاملPrecapillary Systemic-pulmonary Anastomoses.
In normal lungs the bronchial arteries communicate with the pulmonary arteries through the capillary bed surrounding the respiratory bronchioles (Miller, 1947). Whether precapillary communications exist in normal lungs is open to question, but their development under abnormal circumstances is generally agreed. Liebow, Hales, and Bloomer (1959) have summarized the two main circumstances under wh...
متن کاملThe increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis.
BACKGROUND The human ST2 gene can be specifically induced by growth stimulation in fibroblastic cells, and the soluble ST2 protein (ST2) is expressed preferentially in T-helper type 2 (Th2) cells. Furthermore, ST2 is induced by proinflammatory stimuli such as tumor necrosis factor-alpha and interleukin-1 beta. It has been reported that the inflammatory response in idiopathic pulmonary fibrosis ...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2020
ISSN: 1734-1922,1896-9151
DOI: 10.5114/aoms.2020.98635